Table 1.
A listing of current and recently completed oncolytic virotherapy trials. A search was performed on www.clinicaltrials.gov and the clinical trial database of the Journal of Gene Medicine (http://www.wiley.com/legacy/wileychi/genmed/clinical/).
| Virus | Name | Modifications | Phase | Tumor | Route | Combination | Site | Status* (PubMed reference) |
|---|---|---|---|---|---|---|---|---|
| Adenovirus | Oncorine (H101) | E1B-55k-E3− | II | SCCHN | IT | Cisplatin | Multileft | Completed, PMID: 14693057 |
| III | SCCHN | IT | Cisplatin | Multileft | Completed, PMID: 15601557 | |||
| Onyx-015 | E1B-55k-E3B− | I | Lung Mets | IV | - | Mutlileft | Completed, PMID: 11420638 | |
| I | Glioma | Intracavity | - | Mutlileft | Completed, PMID: 15509513 | |||
| I | Ovarian Ca | IP | - | Mutlileft | Completed, PMID: 11896105 | |||
| I | SCCHN | IT | - | Multileft | Completed, PMID: 10741699 | |||
| I | Solid tumors | IV | Enbrel | Mary Crowley | Completed, PMID: 17704755 | |||
| I | Sarcoma | IT | Mitomycin-C Dox, cisplatin | Mayo Clinic | Completed, PMID: 15647767 | |||
| I/II | PanCa | IT | Gemzar | UCLA | Completed, PMID: 12576418 | |||
| II | CRC | IV | - | Mutlileft | Completed, PMID: 12697873 | |||
| II | Hepatobiliary | IT | - | Montefiore | Completed, PMID: 12576437 | |||
| II | CRC, PanCa | IA | - | Mutlileft | Completed, PMID: 12414631 | |||
| II | SCCHN | IT | - | Multileft | Completed, PMID: 11208818 | |||
| II | SCCHN | IT | Cisplatin, 5-FU | Multileft | Completed, PMID: 10932224 | |||
| II | CRC | IV | 5-FU/leucovorin | Stanford | Completed, PMID: 15803147 | |||
| CG7060 | PSA control | I | Prostate Ca | IT | RT | Johns Hopkins | Completed, PMID: 11606381 | |
| CG7870/CV787 | rat probasin-E1A hPSA-E1B E3+ | I/II | Prostate Ca | IV | - | Multileft | Completed, PMID: 16690359 | |
| I/II | Prostate Ca | IV | Docetaxel | Mary Crowley | Terminated, 2005 | |||
| CG0070 | E2F-1, GM-CSF | II/III | Bladder Ca | Intracavity | - | UCSF | Not yet open, PMID: 16397056 | |
| Telomelysin | hTERT | I | solid tumors | IT | - | Mary Crowley | Completed, PMID: 19935775 | |
| Ad5-CD/TKrep | CD/TK | I | Prostate Ca | IT | 5-FC & GCV | Henry Ford, Detroit | Completed, PMID: 12208748 | |
| I | Prostate Ca | IT | 5-FC+GCV+RT | Henry Ford, Detroit | Completed, PMID: 14612551 | |||
| Ad5-D24-RGD | RGD, Delta-24 | I | Ovarian Ca | IP | - | UAB | Completed, PMID: 20978148 | |
| I | Glioma | IT | - | MD Andersen | Recruiting | |||
| I/II | Glioma | IT | - | Erasmus Medical left | Recruiting | |||
| Ad5-SSTR/TK-RGD | SSTR, TK, RGD | I | Ovarian Ca | IP | GCV | UAB | Active, PMID: 16397056 | |
| CGTG-102 | Ad5/3, GM-CSF Delta-24 | I/II | Solid tumors | IT | - | Baylor | Not open, PMID: 20664527 | |
| I | Solid tumors | IT/IV | Metronomic CTX | Docrates Hospital Helsinki | Recruiting | |||
| INGN-007 (VRX-007) | wtE1a, ADP | I | Solid tumors | IT | - | Mary Crowley | Not open, PMID: 19197324 | |
| ColoAd1 | Ad3/11p | I/II | CRC, HCC | - | PsiOxus | Not open, PMID: 18560559 | ||
| Coxsackie Virus (CVA21) | CAVATAK | - | I | Melanoma | IT | - | Viralytics | Completed |
| II | Melanoma | IT | - | Viralytics | Recruiting | |||
| I | SCCHN | IT | Viralytics | Terminated | ||||
| I | Solid tumors | IV | - | Viralytics | Recruiting | |||
| Herpes Simplex Virus | Talimogene Laherparepvec (OncoVEX) | GM-CSF | I | Solid tumors | IT | - | Multileft | Completed, PMID: 17121894 |
| ICP34.5(−) | II | Melanoma | IT | - | Multileft | Completed, PMID: 19915919, 19884534 | ||
| ICP47(−) | III | Melanoma | IT | - | Multileft | Active | ||
| Us11 ↑ | I/II | SCCHN | IT | RT, Cisplatin | Multileft | Completed, PMID: 20670951 | ||
| G207 | ICP34.5(−), ICP6(−) LacZ(+) | I/II | Glioma | IT | - | U of Alabama | Completed, PMID: 18957964, 10845725 | |
| I | Glioma | IT | RT | U of Alabama | Completed | |||
| G47Delta | From G207, ICP47− | I | Glioma | IT | - | Tokyo Hospital | Recruiting, PMID: 11353831 | |
| HSV 1716 (Seprehvir) | ICP34.5(−) | I | Non-CNS solid tumors | IT | - | Cincinnati | Recruiting | |
| I | SCCHN | IT | - | U of Glasgow | Completed, PMID: 18615711 | |||
| I | Glioma | IT | - | U of Glasgow | Completed, PMID: 15334111, 11960316 | |||
| I | Melanoma | IT | - | U of Glasgow | 11229673, 2001 | |||
| I | Mesothelioma | IP | - | UK | not active | |||
| HF10 | HSV-1 HF strain | I | Solid tumors | IT | - | Multileft | Recruiting | |
| I | Pancreatic Ca | IT | - | Nagoya University | Completed, PMID: 21102422 | |||
| I | Breast Ca | IT | - | Nagoya University | Completed, PMID: 16865590 | |||
| I | SCCHN | IT | - | Nagoya University | Completed, PMID: 16923721 | |||
| NV1020 | I | CRC liver mets | IA | - | MSKCC | Completed, PMID: 19018254 | ||
| Measles Virus (Edmonston) | MV-CEA | CEA | I | Ovarian Ca | IP | - | Mayo Clinic | Completed, PMID:20103634 |
| I | Glioma | IT | - | Mayo Clinic | Recruiting | |||
| MV-NIS | NIS | I | Myeloma | IV | CTX | Mayo Clinic | Recruiting | |
| I | Ovarian Ca | IP | - | Mayo Clinic | Recruiting | |||
| I | Mesothelioma | IP | - | U of Minnesota/Mayo Clinic | Recruiting | |||
| I | SCCHN | IT | - | Mayo Clinic | Not open | |||
| Newcastle Disease Virus | NDV-HUJ | - | I/II | Glioma | IV | - | Goldyne Savad Inst | Completed, PMID: 16257582 |
| PV701 | - | I | Solid tumors | IV | - | Ottawa Hospital | Completed, PMID: 16638865 | |
| MTH-68/H | - | II | Solid tumors | Inhalation | - | UCRI | Completed, PMID: 8275514 | |
| NV1020 | I | Solid tummors | IV | - | Multileft | Completed, PMID: 11980996 | ||
| Parvovirus | H-1PV | - | I/II | Glioma | IT/IV | - | University Hospital Heidelberg | Recruiting, PMID: 20299703 |
| Poliovirus (Sabin) | PVS-RIPO | IRES | I | Glioma | IT | - | Duke | Recruiting, PMID: 20299272 |
| Reovirus (Dearing) | Reolysin | - | I/II | Glioma | IT | - | Multileft | Completed, PMID: 18253152 |
| I | Peritoneal Ca | IP | - | Ohio State | Recruiting | |||
| I | Solid tumors | IV | - | Multileft | Completed, PMID: 18981012 | |||
| I | Solid tumors | IV | CTX | Multileft | Recruiting | |||
| I | CRC | IV | FOLFIRI | Multileft | Recruiting | |||
| II | Sarcoma | IV | - | Multileft | Completed | |||
| II | Melanoma | IV | - | Multileft | Suspended | |||
| II | Ovarian, Peritoneal Ca | IV | PTX | Mutlileft | Recruiting | |||
| II | Pancreatic Ca | IV | PTX, CBDCA | Multileft | Recruiting | |||
| II | SCCHN | IV | PTX, CBDCA | Multileft | Not recruiting | |||
| II | Melanoma | IV | PTX, CBDCA | U of Texas | Recruiting | |||
| II | Pancreatic Ca | IV | Gemzar | U of Texas | Recruiting | |||
| II | Lung Ca | IV | PTX, CBDCA | Multileft | Recruiting | |||
| III | SCCHN | IV | PTX, CBDCA | Multileft | Recruiting | |||
| Seneca Valley Virus | NTX-010 | II | Small Cell Lung Ca | IV | - | NCCTG multileft | Recruiting, PMID: 17971529 | |
| Retrovirus | Toca 511 | CD | I/II | Glioma | IT | 5-FC | Multileft | Recruiting, PMID: 16257382 |
| Vaccinia (Wyeth strain) | JX-594 | GM-CSF TK(−) | I | CRC | IV | - | South Korea | Recruiting |
| I | Solid tumors | IV | - | Multileft | Completed | |||
| I | HCC | IT | - | Busan, South Korea | Completed, PMID: 18495536 | |||
| I | Pediatric solid tumors | IT | - | Cincinnnati | Recruiting | |||
| I | Melanoma | IT | - | Busan, South Korea | Completed, PMID: 21772252 | |||
| I/II | Melanoma | IT | - | Multileft | Completed. PMID: 10505851 | |||
| II | HCC | IT | - | Multileft | Not recruiting, data analysis | |||
| IIB | HCC | IV | - | Multileft | Recruiting | |||
| I/II | CRC | IV/IT | Irinotecan | Multileft | Recruiting | |||
| II | CRC | IT | - | Ottawa Hospital | Not yet recruiting | |||
| Vaccinia (Western Reserve) | vvDD-CDSR | TK−, VGF− LacZ, CD Somatostatin R | I | Solid tumors | IT/IV | - | U of Pittsburgh | Recruiting PMID: 15336655 |
| Vaccinia (Lister) | GL-ONC1 (GLV-h68) | Renilla Luciferase GFP, β-gal β-glucoronidase | I | Solid tumors | IV | - | Royal Marsden | Recruiting, PMID: 21779374 |
| I/II | Peritoneal Carcinomatosis | IP | University Hospital Tuebingen | Recruiting | ||||
| I/II | SCCHN | IV | RT,Cisplatin | Moores UCSD Cancer left | Recruiting | |||
| Vesicular Stomatitis Virus (Indiana) | VSV-hIFNβ | IFN beta | I | HCC | IT | - | Mayo Clinic | Recruiting |