(A) Representative autoradiograms showing CP55,940-stimulated [35S]GTPγS binding in brains from vehicle and THC-treated mice. Prefrontal cortex is shown in row 1, nucleus accumbens and caudate-putamen in row 2 and hippocampus, lateral amygdala and basomedial amygdala in row 3. (B) Graph representing differences in net-stimulated [35S]GTPγS binding expressed as a percent of net-stimulated binding in vehicle-treated mice. Data are means ± SEM with * p < 0.05 and ** p < 0.01 versus vehicle controls, un-paired, two-tailed Student t-test, n = 8 mice per group.