TABLE 2.
Region | Δ FosB-ir Integrated intensity | |
---|---|---|
VEHICLE | THC | |
Prefrontal cortex | 2.94 ± 0.33 | 4.20 ± 0.47* |
Nucleus accumbens | 1.81 ± 0.22 | 3.39 ± 0.25*** |
Caudate-putamen | 1.56 ± 0.11 | 2.52 ± 0.12*** |
Lateral amygdala | 2.94 ± 0.11 | 4.05 ± 0.08* |
Basomedial amygdala | 1.98 ± 0.11 | 2.13 ± 0.08 |
Hippocampus | 1.40 ± 0.23 | 1.20 ± 0.14 |
ΔFosB-ir was measured in homogenates prepared from brain regions of interest using an antibody against FosB that recognizes all FosB isoforms, as described in Methods. The 35–37 kDa band, defined as ΔFosB, was measured for analysis. Results are expressed as integrated intensity in units of counts-mm2 ± SEM.
p < 0.05
p < 0.001 different from vehicle by Student’s t-test, n=8 mice per group.