Table 1.
Proposed International Classification of Disease-10 (ICD-10) criteria for diagnosis of cancer-related fatigue*
| A | Six or more of the following symptoms have been present every day or nearly every day during the same 2-week period in the past month and at least one of the symptoms is (A1) significant fatigue. |
| A1 | Significant fatigue, diminished energy, or increased need to rest, disproportionate to any recent change in activity level |
| A2 | Complaints of generalized weakness or limb heaviness |
| A3 | Diminished concentration or attention |
| A4 | Decreased motivation or interest to engage in usual activities |
| A5 | Insomnia or hypersomnia |
| A6 | Experience of sleep as unrefreshing or nonrestorative |
| A7 | Perceived need to struggle to overcome inactivity |
| A8 | Marked emotional reactivity (e.g., sadness, frustration, or irritability) to feeling fatigued |
| A9 | Difficulty completing daily tasks attributed to feeling fatigued |
| A10 | Perceived problems with short-term memory |
| A11 | Post-exertional malaise lasting several hours |
| B | The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning |
| C | There is evidence from the history, physical examination, or laboratory findings that the symptoms are a consequence of cancer or cancer therapy |
| D | The symptoms are not primarily a consequence of comorbid psychiatric disorders such as major depression, somatization disorder, somatoform disorder, or delirium |