Table 2.
QT variability and change compared with baseline after sotalol administration
| QT variability | Baselinea | 2 hb | ≥48 hc |
|---|---|---|---|
| QT, ms (±SD) | 384 (±50) | 403 (±53) | 431 (±45) |
| Heart rate, b.p.m. (±SD) | 83 (±24) | 78 (±22) | 69 (±16) |
| QTc Bazett, ms (±SD) | 443 (±37) | 445 (±39) | 453 (±37) |
| ΔQTc Bazett, ms (±SD) | – | 3 (±42) | 11 (±37) |
| QTc, Fridericia, ms (±SD) | 421 (±34) | 429 (±34) | 444 (±34) |
| ΔQTc Fridericia, ms (±SD) | – | 10 (±38) | 25 (±37) |
QT corrections: QTc Bazett QT/RR1/2, QTc Fridericia QT/RR1/3.
SD, standard deviation; b.p.m., beats per minute.
Information available for:
an = 541.
bn = 377.
cn = 503.