60 year-old woman with voriconazole-induced periostitis following heart transplant. At presentation, anterior and posterior (A, B) whole body views were obtained 3 hours following the intravenous injection of 19 mCi of Tc-99m MDP (ADAC Vertex Gamma Camera), with coned down views of the thorax from A and B shown in E and F, respectively. There are multiple abnormal scattered foci of uptake, most prominent at the medial left proximal humeral neck and the left sixth and seventh ribs (arrows) but also involving the medial right humeral neck (arrow); the bilateral proximal femoral diaphyses, inferior to the lesser trochanters (dashed arrows); and the proximal tibial diaphyses (dashed arrows). Five months following discontinuation of voriconazole, anterior and posterior whole body views (C and D) were obtained 3 hours following the intravenous injection of 20.1 mCi Tc-99m MDP which demonstrate marked interval resolution of the previously noted abnormal foci of uptake (ADAC Vertex Gamma Camera).