Table 1.

Summary table for voriconazole-induced periostitis

Etiology	Likely fluoride excess
Incidence	Unknown, however a small case control study of 20 patients noted radiographic evidence in 50%
Gender Ratio	No specific gender predilection noted
Age Predilection	Predominantly middle-aged adults
Risk Factors	Chronic voriconazole exposure
Treatment	Cessation of voriconazole therapy
Prognosis	Resolution of symptoms and radiographic findings following withdrawal of the medication
Findings on Imaging	Dense, irregular, bulky periosteal new bone formation on radiograph/CT. Associated increased uptake on Tc-99m MDP whole body bone scan