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. 2013 Sep 10;81(11):956–963. doi: 10.1212/WNL.0b013e3182a43b48

Figure 3. Immunocytochemistry demonstrates the presence of RBPJ autoantibodies in the CSF of patients with multiple sclerosis.

Figure 3

Images from testing a representative multiple sclerosis (MS) CSF specimen (19470) are shown on the top row. Recombination signal binding protein for immunoglobulin kappa J region (RBPJ) expression was confirmed through detection with an anti-DDK antibody (green). Strong reactivity to RBPJ by autoantibodies (red) in the CSF from this patient with MS is demonstrated by the colocalization (merge) of the signals. The bottom row shows lack of reactivity by a control CSF (other inflammatory neurologic diseases). RRMS = relapsing-remitting multiple sclerosis.