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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: Front Biosci (Landmark Ed). 2010 Jun 1;15:872–882. doi: 10.2741/3651

Figure 2.

Figure 2

Comparison of predicted subunit topologies of TRPV1 (A) with TRPV1 splice variants (B-D). Splice variant VR.5’sv (B) is identical to TRPV1 except for a dramatically modified N-terminal intracellular region that retains only a small portion of the third ankyrin repeat domain. TRPV1b (C) is identical to TRPV1 except for the partial deletion of the third ankyrin repeat domain and adjoining polypeptide sequence. TRPV1var (D) is unlike TRPV1 or the TRPV1 splice variants as it completely lacks both transmembrane spanning and C-terminal intracellular regions. TRPV1var encodes a truncated N-terminal intracellular region retaining the first ankyrin repeat domain. Despite differences in their predicted N-terminal intracellular regions, there is evidence to support the formation of heteromeric complexes between TRPV1 and the TRPV1-splice variants.