Table 1.
Clinical Outcomes of Subjects After Challenge With Campylobacter jejuni CG8421
| Outcome | All Naive | Veteran |
|---|---|---|
| No. | 15 | 8 |
| Met primary endpoint of campylobacteriosis, No. (%) | 14 (93) | 8 (100) |
| Any diarrhea, No. (%) | 14 (93) | 8 (100) |
| Severe diarrhea, No. (%) | 8 (53) | 7 (88) |
| Time in hoursto campylobacteriosis, median (IQR) | 52.3 (46.9–56.1) | 53.7 (48.3–73.7) |
| Time in hours to first diarrheal stool, median (IQR) | 45.9 (43.7–51.2) | 51.1 (37.0–67.3) |
| Number of diarrhea stools, grade 3–5, median (IQR) | 14 (7–17) | 13 (11–16) |
| Highest 24-h stool output number, grade 3–5, median (IQR) | 7 (4–10) | 8 (6–10) |
| Highest 24-h stool output volume, mL, grade 3–5, median (IQR) | 661 (406–754) | 710 (574–859) |
| Total diarrhea volume, mL, median (IQR) | 1122 (493–1621) | 1122 (900–1669) |
| Time in hours to first antibiotic dose, median (IQR) | 57.0 (48.0–86.0) | 58.1 (46.7–76.4) |
| Gastrointestinal symptoms, No. (%) | ||
| Nausea | 11 (73)a | 2 (25)a |
| Vomiting | 0 (0.0) | 1 (13) |
| Abdominal pain/cramping, any | 14 (93) | 6 (75) |
| Abdominal pain/cramping, severe | 3 (20) | 0 (0) |
| Dysentery | 02 (13.3) | 1 (13) |
| Systemic symptoms, No. (%) | ||
| Fever | 8 (53) | 2 (25) |
| Headache | 12 (80) | 5 (63) |
| Diarrheal disease Severity index,b median (range) | 9.5 (01–14) | 8 (4–11) |
Abbreviation: IQR, interquartile range.
a No associations were statistically significant, except nausea. P = .04.
b See [8].