Table 3.
Demographic and phenotypic characteristics of COGA and COGEND African American and European American samples
| CHRNB3 |
CHRNA3 |
|||||
|---|---|---|---|---|---|---|
| Non-carriers | Carriers | P-value | Non-carriers | Carriers | P-value | |
| COGA European Americans | ||||||
| No. of individuals | 4124 | 44 | – | 3765 | 398 | – |
| Age (years) | 37 ± 16 | 37 ± 15 | 0.95 | 39 ± 15 | 40 ± 15 | 0.37 |
| Women/men | 2076/2048 | 25/19 | 0.51 | 1878/1887 | 185/213 | 0.21 |
| Cigarettes per day | 21 ± 13 | 19 ± 12 | 0.6 | 20 ± 13 | 20 ± 13 | 0.86 |
| Alcohol-dependent cases–controls | 1796/2328 | 22/22 | 0.01 | 1634/2128 | 177/221 | 0.71 |
| Alcohol symptom count | 2.07 ± 2.4 | 2.27 ± 2.7 | 5.6 × 10−4 | 2.9 ± 2.51 | 3.04 ± 2.48 | 0.28 |
| Cocaine-dependent cases–controls | 677/3447 | 12/32 | 0.005 | 601/3158 | 77/320 | 0.1 |
| Cocaine symptom count | 0.65 ± 1.8 | 1.3 ± 2.5 | 2.4 × 10−4 | 1.03 ± 2.21 | 1.16 ± 2.3 | 0.26 |
| COGA African Americans | ||||||
| No. of individuals | 1121 | 143 | – | 1237 | 27 | – |
| Age (years) | 36 ± 13 | 37 ± 13 | 0.34 | 36 ± 12 | 33 ± 11 | 0.19 |
| Women/men | 503/618 | 64/79 | 1 | 558/679 | 9/18 | 0.24 |
| Cigarettes per day | 14 ± 11 | 14 ± 10 | 0.82 | 14 ± 10 | 16 ± 11 | 0.25 |
| Alcohol-dependent cases–controls | 530/590 | 74/69 | 0.32 | 595/641 | 9/18 | 0.17 |
| Alcohol symptom count | 2.99 ± 2.51 | 3.32 ± 2.56 | 0.13 | 3.04 ± 2.52 | 2.66 ± 2.18 | 0.445 |
| Cocaine-dependent cases–controls | 344/768 | 51/92 | 0.25 | 388/840 | 7/20 | 0.67 |
| Cocaine symptom count | 2.02 ± 2.91 | 2.30 ± 3.02 | 0.29 | 1.14 ± 2.4 | 0.81 ± 1.8 | 0.006 |
| COGEND European Americans | ||||||
| No. of individuals | 2036 | 11 | – | 1869 | 178 | – |
| Age (years) | 36 ± 5 | 36 ± 5 | 0.96 | 37 ± 5 | 36 ± 6 | 0.14 |
| Women/men | 1247/789 | 41489 | 0.54 | 1142/727 | 113/65 | 0.57 |
| Cigarettes per day | 18 ± 17 | 18 ± 19 | 0.99 | 19 ± 17 | 17 ± 17 | 0.14 |
| Alcohol-dependent cases–controls | 464/1530 | 4/7 | 0.3 | 434/1395 | 34/142 | 0.22 |
| Alcohol symptom count | 1.72 ± 1.66 | 1.81 ± 1.72 | 0.852 | 1.74 ± 1.67 | 1.50 ± 1.55 | 0.06 |
| Cocaine-dependent cases–controls | 131/1905 | 1/10 | 0.52 | 126/1743 | 6/172 | 0.11 |
| Cocaine symptom count | 0.43 ± 1.44 | 0.55 ± 1.81 | 0.8 | 0.45 ± 1.48 | 0.26 ± 1.12 | 0.08 |
| COGEND African Americans | ||||||
| No. of individuals | 641 | 69 | – | 700 | 10 | – |
| Age (years) | 37 ± 6 | 33 ± 5 | 0.93 | 37 ± 5 | 38 ± 6 | 0.14 |
| Women/men | 408/233 | 41/28 | 0.55 | 1142/727 | 113/65 | 0.57 |
| Cigarettes per day | 16 ± 13 | 16 ± 12 | 0.63 | 16 ± 13 | 12 ± 10 | 0.26 |
| Alcohol-dependent cases–controls | 66/575 | 13/56 | 0.06 | 78/622 | 1/9 | 1 |
| Alcohol symptom count | 1.35 ± 1.72 | 2.00 ± 2.34 | 0.004 | 1.43 ± 1.80 | 1.43 ± 2.6 | 0.99 |
| Cocaine-dependent cases–controls | 43/598 | 6/63 | 0.46 | 49/651 | 0/10 | 1 |
| Cocaine symptom count | 0.71 ± 1.93 | 0.79 ± 2.10 | 0.77 | 0.42 ± 1.54 | 0 ± 0 | 0.39 |
CPD, age, alcohol symptom count and cocaine symptom count values are mean ± SD. P-values for sex and age were calculated with a Fisher's exact test and Wilcoxon Rank-Sum test, respectively. In COGA, P-values for primary phenotypes were calculated using FamSKAT in R using a kinship matrix with age, sex and CPD as covariates. In COGEND, P-values for primary phenotypes were calculated using a Wilcoxon Rank-Sum test.