Table 4.

Causes of graft loss by era

Era	Era 1: pre-CNI (1963–83), n = 72	Era 2a: CNI + steroids (1984–99), n = 117	Era 2b: steroid-free CNI (1999–2011), n = 12	P-value
Causes of graft loss
Acute rejection	0 (0%)	3 (3%)	0 (0%)	0.4
CAN	8 (11%)	29 (25%)	4 (33%)	0.02
Recurrent disease	10 (14%)	8 (7%)	1 (9%)	0.2
Non-compliance	2 (3%)	12 (10%)	0 (0%)	0.1
Death with function	47 (65%)	59 (50%)	7 (58%)	0.1
Other	5 (7%)	6 (5%)	0	0.9

CAN, chronic allograft nephropathy including chronic rejection and CNI toxicity.