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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: Mol Pharmacol. 2008 Mar 27;73(6):1709–1721. doi: 10.1124/mol.108.045591

Scheme 1.

Scheme 1

R and R* represent fractions of channels in activator-free and activator-bound states, D is activator drug, Kon and Koff are binding and unbinding rate constants, and Kd is dissociation constant.