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Concentration-response relationships of PD307243 (A) and NS1643 (B) on hERG current amplitude and gating kinetics. ΔAMP, percentage increase in current amplitude measured as time-dependent current during 1-s step to 0 mV; Δ V0.5, shift in V0.5 of activation; ΔRateINAC, percentage decrease in rate of channel inactivation at 0 mV. Data were averaged from four to six measurements each.
