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. Author manuscript; available in PMC: 2014 Jan 10.
Published in final edited form as: Mol Pharmacol. 2008 Mar 27;73(6):1709–1721. doi: 10.1124/mol.108.045591

Fig. 9.

Fig. 9

An outer pore blocker, TPeA+, or an inner cavity blocker, dofetilide (DOF) prevented the activator effect of PD307243 on hERG. A, cartoon of a TPeA+ ion binding to the outer pore entrance of hERG. B, time course of changes in hERG current amplitude before and after application of 50 μM TPeA+ and after application of increasing concentrations of PD in the continuous presence of TPeA+. Current amplitudes were measured from time-dependent currents during 1-s step to 0 mV and normalized by control. Inset: summary of PD (20 μM)-induced changes in hERG current amplitude in the absence or presence of TPeA+. C and D, the format is the same as that in A and B. DOF binds from the intracellular side of the membrane to the inner cavity.