TABLE 1.

Parameter values used in kinetic model simulation of the effects of PD(307243) and NS(1643) on the hERG channel

Parameter	Control	PD	NS
αao(0) (s −1)	22.3	22.3	22.3
zao	0.294	0.294	0.294
βoa(0) (s −1)	0.047	0.047	0.047
zbo	−1.577	−1.577	−1.577
κf (s−1)	23.8	23.8	23.8
κb (s−1)	36.8	36.8	36.8
αa1(0) (s−1)	13.7	13.7	54.9
za1	0.955	0.955	0.955
βa1(0) (s−1)	0.069	0.069	0.017
zb1	−1.045	−1.045	−1.045
αi(0) (s−1)	90.8	45.4	45.4
zai	0.585	0.585	0.585
βi(0) (s−1)	6.5	6.5	6.5
zbi	−0.817	−0.817	−0.817

See Scheme 2 for kinetic model. The only change in parameter values for PD simulation was a 50% reduction in the “O” to “I” transition rate (highlighted in bold). The changes in parameter values for NS simulation included: 50% reduction in the “O” to “I” transition rate, a 4-fold increase in the “C₂” to “O” transition rate, and a 75% reduction in “O” to “C₂” transition rate (highlighted in bold).