Table 2.
Pharmacokinetic parameters upon oral administration of Fungizone® and AmB-loaded cubosomes
| Formulation | Cmax (ng/mL) | Tmax (h) | t1/2 (h) | AUC0–120 (h · g/mL) |
|---|---|---|---|---|
| Fungizone® 10 mg/kg) | 218.5±30.9 | 6.3±2.3 | 21.4±6.1 | 5,964.0±705.4 |
| AmB-loaded cubosomes (10 mg/kg) | 286.4±35.1 | 25.1±3.7 | 20.2±5.7 | 11,749.1 ±2,231.2 |
Note: Each data point represents the mean ± standard deviation of three determinations.
Abbreviation: AmB, amphotericin B; Cmax, maximum drug concentration; Tmax, time to maximum plasma concentration; t1/2, terminal phase half-life; AUC0-120, area under the curve (0–120 minutes).