Table 2. Areas with significant differences on gray matter volume in single episode participants with major depressive disorder compared to health control participants.

		MNI coordinates
Areas	Cluster Size	x	y	z	F/T values
Between 3 groups
Right dorsolateral prefrontal cortex	68	37	40	8	16.64
Left middle frontal gyrus	137	−36	15	26	15.45
Right insula	50	43	0	3	15.14
nMDD<HC
Right dorsolateral prefrontal cortex	112	37	40	8	5.64
Left middle frontal gyrus	82	−36	19	42	4.69
nMDD>HC
Left thalamus	93	−5	−14	11	3.78
Right insula	85	43	0	3	5.31
tMDD>HC
Left middle frontal gyrus	340	−36	15	26	5.10
Right orbitofrontal cortex	372	11	63	−6	4.85

nMDD: medication-naïve major depressive disorder.

tMDD: treated major depressive disorder.

HC: healthy controls.