Table 3. Comparison of Na+, Cl− and Ca2+ channel subunits, Ca2+ handling proteins and exchanger expression levels between myopathic and normal LV's.
Subunit | Normal | Myopathic | P-value |
Nav1.3 | 3.51±0.78 | 6.80±1.02 | 0.022 |
Nav2 | 220.88±22.41 | 380.50±53.26 | 0.015 |
Navβ2 | 33.40±8.42 | 74.81±3.48 | <0.001 |
Cav3.2 | 3.49±0.26 | 8.08±1.51 | 0.010 |
Cavα2δ1 | 159.86±15.38 | 236.21±15.84 | 0.004 |
CFTR | 2.27±0.64 | 0.15±0.04 | 0.015 |
Na/K ATPase α3 | 1599.52±146.13 | 1128.90±70.86 | 0.012 |
Na/K ATPase β1 | 1119.32±74.20 | 836.58±30.03 | 0.003 |
SERCA2 | 4635.35±333.73 | 2214.78±160.50 | <0.001 |
PLN | 16292.37±1380.77 | 8658.84±460.77 | <0.001 |
CASQ2 | 2108.07±90.71 | 2671.54±121.65 | 0.002 |
Units for all values are 2−ΔCt versus reference gene (×100), expressed as mean ± SEM. Only expression comparisons achieving p<0.05 are presented.