Table 2. Univariable and multivariable analysis for disease-free survival with clinicopathologic prognostic factors.

	Disease Free Survival
	Univariable hazard ratio (95% CI)	p-value	Multivariable hazard ratio (95% CI)	p-value
Integration Pattern		(0.098)		(0.014)
Group1	1		1
Group2+3	1.90 (0.70, 5.15)	0.207	3.15 (1.12,8.90)	0.03
Group4	3.52 (1.11,11.14)	0.032	6.78 (1.86,24.79)	0.004
HPV type
16	1
18	1.89 (0.84, 4.23)	0.124
58	0.92 (0.22, 3.92)	0.914
Stage group				(0.005)
∼IIB	1		1
III/IVA	2.79 (1.25, 6.21)	0.012	3.83 (1.56, 9.39)	0.003
IVB	4.33 (1.59, 11.78)	0.004	3.62 (1.15,11.44)	0.028
Nodal state
Negative	1		1
Positive	2.75 (1.19, 6.36)	0.018	1.14 (0.40, 3.19)	0.81
Histologic Grade
well/moderate	1		1
Poor	1.97 (0.91, 4.26)	0.083	2.53 (1.01, 6.34)	0.047
Histologic type
SCC	1
AD/ASC	2.301 (0.94, 5.65)	0.069
Smoking
Never	1
Ever	1.65 (0.71, 3.81)	0.244
Age *	0.85 (0.75,0.97)	0.014	0.93 (0.69, 0.98)	0.034

Abbreviations: AD/ASC, adenocarcinoma/adenosquamous carcinoma; SCC, squamous cell carcinoma.

5-year increase in age.