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. Author manuscript; available in PMC: 2014 Jan 11.
Published in final edited form as: Nat Struct Mol Biol. 2012 Jan 22;19(2):201–206. doi: 10.1038/nsmb.2211

Fig 4. Accumulation of K48-linked and K63-linked ubiquitin chains at DNA damage sites.

Fig 4

(a) Rnf8+/+ and Rnf8−/− MEF cells were treated with laser mirco-irradiation and immunostained 5 minutes later using indicated antibodies. (b) Time course analysis of K48-linked and K63-linked ubiquitin chain formation at DNA damage sites. U2OS cells were fixed at the indicated time points after microirradiation. (c) Working model of the possible roles of RNF8 and RNF168 in DNA damage response.