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. 2013 Oct 29;122(1):34–42. doi: 10.1289/ehp.1307280

Figure 5.

Figure 5

Effect of LPS on induction of effector and regulatory responses by HDEs. Values are shown as the mean ± SE cell number of total leukocytes, eosinophils, and neutrophils in BALF. (A,B) Mice were sensitized with OVA together with Endolo or Endomod HDEs and challenged with OVA on a single occasion or on six occasions. (A) Dose response for Endolo or Endomod HDEs in C57BL/6J mice. (B) Contribution of LPS component of HDEs to airway leukocytes in Tlr4-deficient (Tlr4–/–) and wild-type (WT C57BL/6J) mice sensitized to OVA using 20 μL of HDE and then challenged as described above. Data in (A) and (B) are from one of two experiments yielding similar results (n = 6 mice/group). (C) C57BL/6J mice were sensitized to OVA using Endolo HDE alone or supplemented with LPS and challenged as described above. Eosinophilic inflammation was inhibited in HDE plus LPS mice. Data are from a single experiment (n = 6 mice/group). *p < 0.05 compared with 0 μL HDE (OVA-only controls). **p < 0.05 for 20 μL compared with the lower HDE dose. #p < 0.05 compared with WT. ##p < 0.05 compared with HDE alone.