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. 2013 Sep 25;73(1):56–61. doi: 10.1136/annrheumdis-2013-203674

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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Graphical representation of change from baseline to week 26 for candidate serum biomarkers. There were no statistically significant changes in von Willebrand factor (vWF; A) or sIL-2R (panel B) between baseline and end of study. However, PIIINP (C) showed significant increase in the active treatment arm compared with the placebo group. This novel observation may reflect increased connective tissue remodelling in late-stage SSc cases receiving active treatment as it occurs in the context of improvement in average skin score.