Figure 2.
Mean absolute neutrophil counts in rhesus macaques following total-body irradiation and administration of filgrastim or control. Animals (n=80) were exposed to 7.50 Gy total body irradiation (TBI) with 6MV LINAC-derived photons at a dose rate of 0.80 Gy/min and administered medical management and either filgrastim (n=40) or control (5% dextrose in water) (n=40) by subcutaneous injection beginning on d2 post-TBI. Shown is the decrease in the absolute neutrophil count (ANC) in the peripheral blood of rhesus macaques as a function of time post-TBI. Mean values (± standard error) are displayed for all animals that survived at each data point.