Table 1.
A proposed model of dynamic trait and state related brain changes in eating disorders
| Possible premorbid trait | Active illness | |||||
|---|---|---|---|---|---|---|
| Diagnostic group | Alteration | Laterality | Diagnostic group | Alteration | Laterality | |
| Brain structure | ||||||
| Insula volume | AN | Increase ↑ | Right | AN | Increase ↑ | Right |
| BN | ?? | BN | Increase ↑ | Left | ||
| Orbitofrontal cortex volume | AN | Increase ↑ | Left | AN | Increase ↑ | Left |
| BN | ?? | BN | Increase ↑ | Left | ||
| Brain function (activation) | ||||||
| Random (unpredictable) Taste reward stimulation | ||||||
| Insula | AN | Increase ↑ | Right | AN | Increase ↑ | Right |
| BN | ?? | BN | Decrease ↓ | Right, Left | ||
| Ventral striatum | AN | Increase ↑ | Left | AN | Increase ↑ | Left |
| BN | ?? | BN | Decrease ↓ | Right | ||
| Repeated (predictable) Taste reward stimulation | ||||||
| Insula | AN | Decrease ↓ | Right | AN | ?? | |
| BN | Increase ↑ | Right | BN | ?? | ||
| Anxiety provocation | ||||||
| Frontal cortex with anterior cingulate | AN | Increase ↑ | Right, Left | AN | Increase ↑ | Right, Left |
| BN | Increase ↑ | Right, Left | BN | Increase ↑ | Right, Left | |