Table 6.
RR of all-cause mortality (excluding suicide) or cardiac mortality in users of atypical and typical antipsychotics.
| Outcome | Type of antipsychotic | No. of cases | Incidence rate per 1000 person-years | Age, sex-adjusted relative risk (RR) (95% CI) | Fully adjusted RR (aRR) (95% CI) |
|---|---|---|---|---|---|
| All-cause mortality | Typical | 15,334 | 91.5 | Reference | Reference |
| Atypical | 7,555 | 76.0 | 0.79 (0.77–0.81)‡ | 0.83 (0.80–0.85)‡ | |
| Cardiac mortality | Typical | 1,130 | 17.8 | Reference | Reference |
| Atypical | 1,214 | 16.1 | 0.84 (0.78–0.91)‡ | 0.89 (0.82–0.97)‡ | |
| SCD primary definition | Typical | 20 | 3.8 | Reference | Reference |
| Atypical | 22 | 2.1 | —(NC#) | —(NC#) | |
| SCD secondary definition | Typical | 77 | 14.5 | Reference | Reference |
| Atypical | 95 | 9.1 | 0.72 (0.53–0.97)† | 0.76 (0.55–1.04)* | |
| SCD tertiary definition | Typical | 97 | 6.3 | Reference | Reference |
| Atypical | 99 | 3.7 | 0.66 (0.50–0.87)‡ | 0.70 (0.53–0.93)† | |
| CHD | Typical | 867 | 6.3 | Reference | Reference |
| Atypical | 459 | 5.1 | 0.80 (0.72–0.90)‡ | 0.85 (0.76–0.96)‡ | |
| Ventricular arrhythmias | Typical | 382 | 2.8 | Reference | Reference |
| Atypical | 242 | 2.7 | 0.94 (0.80–1.10) | 0.93 (0.79–1.10) |
*P < 0.10, † P < 0.05, ‡ P < 0.01, #Not calculable due to small number of cases.