(b) Highly ranked genes nearby SNPs conferring susceptibility to obesity
Gene symbol | Official full name | Location | Percentage | References | SNPs (Chr pos; frequencies) |
---|---|---|---|---|---|
NCKAP5L | NCK-associated protein 5-like | Chr12 50,184,929-50,222,208 (−): 12q13.12 |
63.6% | rs7132908 (50,263,148; G = 0.73; A = 0.27) |
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SP1 | Sp1 transcription factor | Chr12 53,773,979-53,810,230 (+): 12q13.12 |
63.6% | rs1443512 (54,342,684; A = 0.31; C = 0.69) |
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ITGA5 | Integrin, alpha 5 | Chr12 54,789,045-54,813,050 (−): 12q11-q13 |
58.3% | rs1443512 (54,342,684; A = 0.31; C = 0.69) |
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TOMM5 | Translocase of outer mitochondrial membrane 5 | Chr9 37,588,410-37,592,636 (−): 9p13.2 |
57.1% | rs16933812 (36,969,205; G = 0.40, T = 0.60) |
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HSP90AB1 | Heat shock protein 90 kDa alpha (cytosolic), class B member 1 | Chr6 44,214,849-44,221,614 (+): 6p12 |
55.6% | rs6905288 (43,758,873; G = 0.38, A = 0.62) |
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BAP1 | BRCA1 associated protein-1 | Chr3 52,435,024-52,444,009 (−): 3p21.31-p21.2 |
50% | rs6784615 (52,506,426; C = 0.04, T = 0.96) |
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GRB14 | Growth factor receptor-bound protein 14 | Chr2 165,349,323-165,478,360 (−): 2q22-q24 |
50% | Cooney et al., 2004 [18]; Holt et al., 2009. [19] | rs10195252 (165,513,091; T = 0.60, C = 0.40) |
Note: Chr pos: chromosome position; frequencies: the allele frequencies in 1000 genomes (http://www.ncbi.nlm.nih.gov/variation/tools/1000genomes/).