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. 2013 Dec 26;2013:903948. doi: 10.1155/2013/903948

Figure 8.

Figure 8

Behçet's disease (BD)-like symptoms were changed after siTim-4 administration. Five μg/mouse of Tim-4 siRNA was injected intraperitoneally three times at 2 day intervals into BD mice and they were observed for 2 weeks. (a) Photographs of mice taken before and at 1 and 2 weeks after treatment with siTim-4 and the control treated group (Con: negative control siRNA treated groups). (b) The severity score was compared before and at 1 and 2 weeks after treatment between the siTim-4 and control treated groups. The frequencies of Tim-4+ cells in peritoneal cavity were compared between the siTim-4 and control treated groups. (c, d) The frequencies of Tim-4+, CD11b+Tim-4+, CD11c+Tim-4+, Tim-1+, CD4+Tim-1+, and CD8+Tim-1+ cells in LN were compared to the siTim-4 and control treated groups (n = 7-8) (**P < 0.05). Con: negative control injection to BD mice, siTim-4: Tim-4 siRNA injection to BD mice, LN: lymph node.