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Comparison of Imaging characteristics of h131, h131-F(ab′)2 and h131-Fab.
| h131 | h131-F(ab′)2 | h131-Fab | |
|---|---|---|---|
| time-point reaching maximum tumor uptake | 48 h p.i. | 6 h p.i. | 4 h p.i. |
| maximum tumor uptake level | high | medium | low |
| tumor accumulation rate | low | medium | high |
| clearance rate from body | low | medium | high |
| Liver uptake | high | medium | low |
| Kidney uptake | low | medium | high |
| Specificity towards EphB4 receptor in in vivo imaging experiment | Yes, but at late time points | Yes, as early as 4 h p.i. | No |
