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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Jul 12;1841(5):727–737. doi: 10.1016/j.bbalip.2013.07.002

Table 1.

The kinases known to phosphorylate ERM proteins and their functional consequences. (N.B. 1- The ERM column refers to the specific ERM member that is phosphorylated by the corresponding kinase, 2- the numbering of the phosphorylation sites reflects their position in the original ERM sequence; this might slightly differ in the original manuscripts as some authors use their tagged constructs for numbering).

P-site Kinase ERM Stimulus Cell line Function Ref
EzrinThr567, RadixinThr564, MoesinThr558 PKC ERM Amphetamine PC12 cells Synaptic plasticity [50]
E Dinitrosopiperazin NPC cells Motility, invasion, metastasis [92]
E N/A Oteoscarcoma cells Migration and invasion [85, 93]
ERM 2-methoxyestradiol HPAEC cells Hyperpermeability [76]
ERM Glutamate Hippocampal cells Filopodia and synaptic boutons formation [51]
E Latent membrane protein-1 expression NPC cells Motility and invasion [6]
E N/A Intestinal epithelial cells Epithelial differentiation [124]
M Hypotonicity Collecting duct epithelial cells Cytoskeletal remodeling [125]
E Androgen LNCaP-FGC Invasion [126]
E Parathyroid Hormone Oposum Kidney cells Endocytosis [127]
E N/A 2C4 Fibrosarcoma Migration [128]
Rho/ROCK ERM Netrin Cortical Neurones Axonal growth [49]
E Estrogen T47-D Breast cancer cells Migration and invasion [91]
ERM LPA Ovarian Cancer Migration and metastasis [129]
E N/A Hepatoma cells Invasion [90]
E Cisplatin HT29 cells Apoptosis [100]
E N/A NPC cells Metastasis [130]
EM Fas receptor activation Jurkat T cells Apoptosis [131]
E TNF Endothelial cells Inhibition of proliferation [132]
E Net and Dbl overexpression NIH3T3 fibroblasts Malignant transformation [133]
P38 MAPK ERM TNF Synoviocytes Proliferation [63]
M Advanced glycation end products Endothelial cells Hyperpermeability [78]
GRK-2 R Wound closure MDCK cells Migration [134]
ERM Angiotensin-II Kidney Podocytes Actin turnover and migration [135]
E Acetylcholine Hep2 and HEK293 cells Membrane ruffles formation and internalization [136]
NIK ERM EGF, PDGF MTLn3 cells Lamellipodia formation [137]
AKT2 E Glucose Caco-2BBe cells Translocation of NHE-3 to plasma membrane [138]
LRRK2 ERM N/A Primary Neurons Retardation of growth and increased filopodia [52]
Mst-4 E N/A W4 cell line Apical brush border formation [139]
LOK ERM N/A Lymphocytes Decreased migration and polarization [140]
Slik M Mitosis initiation Drosophila S2 cells Cortical microtubular stability [45]
MRCK ERM Cdc42 overexpression NIH3T3 fibroblasts Filopodia Formation [141]

Tyr146 and/or 354 and/or 478 Syk E CD81 engagement B lymphocytes Cell reorganization and signaling [142]
Flt3 E Kit overexpression Proerythroblasts Apoptosis resistance and proliferation [143]
Src E EGF A431 cells Spreading and proliferation [144]
E ICAM1 ligation Endothelial cells N/A [145]
E N/A Hek239 Association with KBTBD2 [146]
Lck E N/A Jurkat T cells Signaling during T cell activation [147]

Thr235 Cdk5 E Overexpression of Retinoblastoma Osteosarcoma Cell senescence and flat cell morphology [148-150]

Ser66 PKA E Histamine Gastric Parietal cells Acid secretion [55, 56]
HHS Vulnerability Disclosure