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. Author manuscript; available in PMC: 2014 Jan 12.
Published in final edited form as: J Control Release. 2012 Oct 24;165(1):62–74. doi: 10.1016/j.jconrel.2012.10.012

Fig. 2.

Fig. 2

Retention of Al(OH)3-sorption capacity after encapsulation in PLGA microspheres. Effect of initial state (hydrated or dry) of Al(OH)3 on ovalbumin (OVA) adsorption as a function of incubation time. Samples studied were unencapsulated Al(OH)3 in hydrated state (●), vacuum-dried (with trehalose as a stabilizer) Al(OH)3 before encapsulation (▲), vacuum-dried Al(OH)3 after encapsulation and polymer removal (○), and 3.2 wt% Al(OH)3/3.5 wt% trehalose/5 wt% DEP/PLGA microspheres (ASM-1, Table 1) (■). All the samples were incubated with 0.4 mL of 1 mg/mL OVA in 10 mM MOPS buffer (pH 7.4) under mild agitation at 25 and 42 °C respectively for 24 and 48 h. The mass of Al(OH)3 in all the samples was about 0.6 mg and symbols represent mean ± SEM, n = 3.