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. Author manuscript; available in PMC: 2014 Jan 12.
Published in final edited form as: J Control Release. 2012 Oct 24;165(1):62–74. doi: 10.1016/j.jconrel.2012.10.012

Fig. 5.

Fig. 5

Aluminum hydroxide (Al(OH)3) suppresses self-healing of PLGA. Effect of encapsulation of aluminum hydroxide (Al(OH)3) or calcium phosphate (CaHPO4) in PLGA microspheres on PLGA healing. Scanning electron microscopic images of Al(OH)3-trehalose-PLGA (A), blank (trehalose/PLGA) (B), and CaHPO4/trehalose/PLGA (C) microspheres before and after active self-healing microencapsulation process. Image A, B, and C respectively correspond to ASM-17, B-1, and ASM-18 in Table 1. Microspheres (20-63 μm in size) were incubated with 0.4 mL of 1 mg/mL OVA in 10 mM MOPS buffer (pH 7.4) under mild agitation at 25 and 43 °C respectively for 24 and 48 h.