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. Author manuscript; available in PMC: 2014 Jan 12.
Published in final edited form as: J Control Release. 2012 Oct 24;165(1):62–74. doi: 10.1016/j.jconrel.2012.10.012

Fig. 6.

Fig. 6

Co-incorporation of hydrophobic plasticizer (diethyl phthalate (DEP)) in PLGA overcomes self-healing suppression induced by Al(OH)3. Scanning electron microscopic image of 0 (A), 2.5 (B), 5 (C), 10 (D), and 20 (E) wt% DEP loaded Al(OH)3-PLGA microspheres before and after active self-healing microencapsulation. Image A, B, C, D, and E respectively correspond to ASM-19, ASM-20, ASM-1, ASM-21 and ASM-22 in Table 1. Microspheres (20-63 μm in size) were incubated with 0.4 mL of 1 mg/mL OVA in 10 mM MOPS buffer (pH 7.4) under mild agitation at 10, 25 and 37 °C respectively for 48, 24, and 30 h.