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. Author manuscript; available in PMC: 2014 Dec 28.
Published in final edited form as: J Control Release. 2013 Sep 8;172(3):662–670. doi: 10.1016/j.jconrel.2013.08.295

Table 1.

Langmuir model fitted parameters (see Eqn 1) and estimated fraction of acids occupied at maximal sorption.

Peptide Polymer K [μM−1] Γ0 [μmol/g PLGA] Γmax[a] [μmol/g PLGA] Total acids [μmol/g PLGA] FA[b]
Leuprolide RG 502H 0.77 1.5 229 185 1.24
Octreotide RG 502H 1.6 8.5 163 185 0.88
Octreotide RG 503H 1.2 2.9 81 94 0.86
Octreotide RG 504H n.d n.d ~6[c] 53 n.d
[a]

Γmax = Γ0 + Γ1

[b]

fraction of acids occupied (Γmax/Total acids).

[c]

Γmax estimated visualy from isotherm.