Table 1.
Peptide | Polymer | K [μM−1] | Γ0 [μmol/g PLGA] | Γmax[a] [μmol/g PLGA] | Total acids [μmol/g PLGA] | FA[b] |
---|---|---|---|---|---|---|
Leuprolide | RG 502H | 0.77 | 1.5 | 229 | 185 | 1.24 |
Octreotide | RG 502H | 1.6 | 8.5 | 163 | 185 | 0.88 |
Octreotide | RG 503H | 1.2 | 2.9 | 81 | 94 | 0.86 |
Octreotide | RG 504H | n.d | n.d | ~6[c] | 53 | n.d |
Γmax = Γ0 + Γ1
fraction of acids occupied (Γmax/Total acids).
Γmax estimated visualy from isotherm.