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Molecular surface representation of (A) OXA-1 and (B) OXA-23. In both cases the bound substrate (doripenem and meropenem, respectively) are shown as cyan ball-and-stick. The motion of the Leu166 side chain in response to meropenem binding in OXA-23 opens a channel to the external solvent and allows access of a water molecule to the N-carboxylated Lys82.
