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Kinetic parameters for hydrolysis of carbapenems by OXA-23
| Parameter | Imipenem | Meropenem | Ertapenem | Doripenem |
|---|---|---|---|---|
| kcat (s−1) | 0.35 ± 0.01 | 0.068 ± 0.001 | 0.021 ± 0.001 | 0.036 ± 0.001 |
| Km (μM) | 4.8 ± 0.3 | ≤1 | 0.50 ± 0.10 | 0.70 ± 0.09 |
| kcat/Km (M−1s−1) | (7.4 ± 0.4) × 104 | ≥6.8 × 104 | (4.2 ± 0.8) × 104 | (5.2 ± 0.7) × 104 |
