Table 3.

Efavirenz original and bootstrap parameter estimates of the final model (n=1,000)

Parameter	Original estimate	Asymptotic RSE	Bootstrap average	Bootstrap RSE	Bootstrap percentile
					2.5	97.5
Fraction with slow clearance of EFV	0.227	32.9%	0.236	33.6%	0.105	0.413
Ratio of CL/F in slow metabolizers to CL/F in fast metabolizers	0.365	11.3%	0.364	13.4%	0.291	0.464
CL/F for EFV (L/h/70 kg)	12.8	7.50%	12.9	8.05%	11.1	15.2
Ratio of CL/F when taking TB treatment to CL/F without TB treatment	0.705	9.20%	0.705	9.6%	0.574	0.836
Proportional residual error	0.120	31.8%	0.119	43.0%	0.028	0.188
Additive residual error (mg/L)	0.462	26.8%	0.466	28.8%	0.221	0.755
Between-subject variability (CL/F)	0.215	36.5%	0.197	23.8%	0.091	0.278
Between-occasion variability in F	0.453	26.6%	0.435	19.5%	0.280	0.562

EFV, Efavirenz; CL/F, apparent clearance, where F is the bioavailability; TB, tuberculosis; RSE, relative standard error