Fig. 4.

Mean (±SEM) responses during the signaled availability and nonavailability periods for food-maintained operant sessions. Left panels (a, c, e, and g) depict responding maintained by food under signaled availability conditions, while right panels (b, d, f, and h) depict responses under signaled nonavailability conditions. Panels a–d compare responding for food pellets between groups of adult rats that earned cocaine or food pellets (cocaine-naïve) during adolescence. Panels e–h compare responding between groups of adult rats that earned cocaine or food pellets (cocaine-naïve) earlier in adulthood. The cocaine-naïve groups are the same as the food retest groups in Fig. 3 and are renamed. Adult females and males exposed to cocaine during adolescence responded more for food during the signaled availability period than cocaine-naïve adult females and males (a and c; *p<0.05). Further, males, whether cocaine-naïve or cocaine-exposed during adolescence or adulthood, responded more than females during the signaled availability period (c and g vs. a and e; †p<0.05). Adult female and male rats with adolescent cocaine exposure make more reinforced responses than females and males that were exposed to cocaine as adults (a and c vs. e and g; @p<0.05)