Table 1.
Summary of Independent Mutations in the cII Gene of Livers of Big Blue® Transgenic Mice Treated with Vehicle, Dibromoethane, BSO/Dibromoethane, or O6-BzGua/ Dibromoethane
| type of mutation | number of independent mutations (%)
|
|||
|---|---|---|---|---|
| vehicle | dibromoethane | BSO/dibromoethane | O6BzGua/ dibromoethane | |
| G:C to C:G | 3 (8) | 0 (0) | 2 (5) | 2 (5) |
| G:C to A:T | 21 (57) | 19 (47.5) | 23 (55) | 13 (34) |
| G:C to T:A | 6 (16) | 13 (32.5) | 7 (17) | 12 (32) |
| A:T to T:A | 2 (5) | 1 (2.5) | 3 (7) | 2 (5) |
| A:T to C:G | 1 (3) | 2 (5) | 1 (2) | 2 (5) |
| A:T to G:C | 0 (0) | 3 (7.5) | 1 (2) | 3 (8) |
| frameshift | 4 (11) | 2 (5) | 4 (10) | 3 (8) |
| other (tandem base substitution) | 0 (0) | 0 (0) | 1 (2) | 1 (3) |
| total mutants screened | 37 (100) | 40 (100) | 42 (100) | 38 (100) |