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. Author manuscript; available in PMC: 2014 Nov 18.
Published in final edited form as: Chem Res Toxicol. 2013 Nov 6;26(11):1765–1774. doi: 10.1021/tx4003534

Table 2.

Summary of Independent Mutations in the cII Gene of Livers of Big Blue® Transgenic Mice Treated with Vehicle, DEB, BSO/DEB, or O6-BzGua/DEB

type of mutation number of independent mutations (%)
vehicle DEB BSO/DEB O6-BzGua/DEB
G:C to C:G 3 (8) 1 (2.5) 1 (2.6) 2 (5)
G:C to A:T 21 (57) 12 (30) 19 (49) 18 (45)
G:C to T:A 6 (16) 8 (20) 10 (25.6) 8 (20)
A:T to T:A 2 (5) 1 (2.5) 1 (2.6) 2 (5)
A:T to C:G 1 (3) 2 (5) 1 (2.6) 1 (2.5)
A:T to G:C 0 (0) 10 (25) 4 (10) 6 (15)
frameshift 4 (11) 5 (12.5) 2 (5) 3 (7.5)
other (tandem base substitution) 0 (0) 1 (2.5) 1 (2.6) 0 (0)
total mutants screened 37 (100) 40 (100) 39 (100) 40 (100)