TABLE 2.
Total numbers and differential distributions of blood leukocytes
| Control mice* | Mutant mice | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total WBC (per mm3) |
Neutrophils | Total WBC (per mm3) |
Neutrophils | ||||||||
| Mouse† | Lymphocytes | Total | Immature | Monocytes | Mouse | Lymphocytes | Total | Immature | Monocytes | ||
| 362F 25(+/+) | 2,400 | 1,896(79) | 432(18) | 0(0) | 24(1) | 166F 22(−/−) | 1,600 | 800(50) | 368(23) | 96(6) | 384(24) |
| 451F 20(ND) | 2,500 | 1,325(53) | 950(38) | 100(4) | 175(7) | 208F 20(−/−) | 1,300 | 715(55) | 429(33) | 39(3) | 156(12) |
| 447M 20(ND) | 2,800 | 1,568(56) | 952(34) | 84(3) | 196(7) | 254M 21(−/−) | 2,000 | 1,180(59) | 400(20) | 100(5) | 320(16) |
| 455F 19(ND) | 2,300 | 1,679(73) | 506(22) | 92(4) | 69(3) | 260F 21(−/−) | 2,500 | 1,650(66) | 600(24) | 250(10) | 225(9) |
| 377F 23(+/+) | 1,600 | 1,072(67) | 384(24) | 64(4) | 144(9) | 374F 23(−/−) | 4,200 | 2,730(65) | 1,050(25) | 168(4) | 378(9) |
| 532F 20(ND) | 2,100 | 1,428(68) | 630(30) | 63(3) | 42(2) | 379F 23(−/−) | 5,500 | 3,245(59) | 1.925(35) | 275(5) | 275(5) |
| 392M 22(+/−) | 2,500 | 1,825(73) | 500(20) | 175(7) | 150(6) | 397M 22(−/−) | 2,500 | 1,225(49) | 1,050(42) | 750(30) | 225(9) |
| 425M 37(ND) | 4,500 | 3.510(78) | 945(21) | 0(0) | 45(1) | 418M 37(−/−) | 4,000 | 2,080(52) | 1,640(41) | 600(15) | 200(5) |
| 471F 29(+/−) | 3,700 | 2,812(76) | 814(22) | 37(1) | 74(2) | 473F 29(−/−) | 5.000 | 2,350(47) | 2,150(43) | 500(10) | 400(8) |
| mean | 2,711 | 1,902(69) | 679(25) | 68(3) | 102(4) | 3,178 | 1,775(56) | 1,068(32) | 309(10) | 285(11) | |
| ±s.d. | ±877 | ±777(±9) | ±237(±7) | ±54(±2) | ±64(±3) | ±1,531 | ±883(±7) | ±689(±9) | 4251(±8) | ±89(±6) | |
| P value‡ | P> 0.05 | P> 0.05 | P>0.05 | P< 0.02 | P<0.01 | ||||||
Absolute number of cells per mm3 is given followed by percentage in parentheses. WBC, white blood cells.
*
Control mice were sex, parent and, as closely as possible, age matched.
†
The mouse number is followed by sex, age at death or sacrifice (days), and genotype (ND, not determined, phenotypically normal).
‡
t-test of paired comparisons between control and mutant animals.