. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Acta Neuropathol. 2013 Jul 18;126(2):161–177. doi: 10.1007/s00401-013-1154-1

Table 2.

Synopsis of differences and overlap between Hs-Aging and other related brain diseases

Disease	Mesial temporal sclerosis	Clinical syndrome(S)			Age range (most cases)	Location of aberrant TDP-43 in brain	Genes
Disease	Mesial temporal sclerosis	Early amnesia	Aphasia/semantic	Behavior variant	Age range (most cases)	Location of aberrant TDP-43 in brain	Genes
Epilepsy	Y				Usually <40	None	Many
Vascular insufficiency	Y	Y			Any age	None	N/A
FTLD-TDP	Y		Y	Y	40–75	Very widespread	GRN, VCP, C9orf72
AD	Y	Y			60–100	Not part of “classic” AD	APOE, PSEN1, PSEN2, APP
HS-Aging	Y	Y			>85	Hippocampus and amygdala	(?)