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Whipp’s law for ventilatory compensation of changes in physiological VD/VT during exercise. Homeostatic regulation of PaCO2 during moderate exercise in healthy subjects (panel a) implies that decreases in physiological VD/VT with exercise (panel b) must be accompanied by corresponding decreases in V̇E/V̇CO2 (panel c). As a result, the V̇E − V̇CO2 relationship shows a positive intercept on the Y-axis (panel d). Data adapted from Table 1 in Whipp and Wasserman (1969).
