Table 1. Summary results for the tested SNPs in 252 patients with unexplained adenomatous polyposis and 745 healthy controls.
Allele* |
MAF | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Chr | SNP | Base-pair position† | Minor | Major | Patients | Controls | p Value | OR (95% CI) | Gene | Reference |
1q41 | rs6691170 | 222045446 | T | G | 0.378 | 0.346 | 0.194 | 1.1 (0.9-1.4) | DUSP10 CICP13 | 32 |
1q41 | rs6687758 | 222164948 | G | A | 0.228 | 0.197 | 0.141 | 1.2 (0.9 to 1.5) | DUSP10 CICP14 | 32 |
3q26.2 | rs10936599 | 169492101 | T | C | 0.237 | 0.244 | 0.745 | 1.0 (0.8 to 1.2) | MYNN | 32 |
8q23.3 | rs16892766 | 117630683 | C | A | 0.086 | 0.086 | 0.998 | 1.0 (0.7 to 1.4) | TRPS1 EIF3H | 33 |
8q24.21 | rs6983267 | 128413305 | G | T | 0.575 | 0.530 | 0.078 | 1.2 (1.0 to 1.5) | POU5F1 MYC | 34 |
10p14 | rs10795668 | 8701219 | A | G | 0.290 | 0.324 | 0.154 | 0.9 (0.7 to 1.1) | KRT8P16 TCEB1P3 | 33 |
11q23 | rs3802842 | 111171709 | C | A | 0.355 | 0.256 | 0.00002 | 1.6 (1.3 to 2.0) | C11orf93 | 11 |
12q13.13 | rs7136702 | 50880216 | T | C | 0.357 | 0.327 | 0.222 | 1.1 (0.9 to 1.4) | TBX3 UBA52P7 | 32 |
12q13.13 | rs11169552 | 51155663 | T | C | 0.260 | 0.264 | 0.876 | 1.0 (0.8 to 1.2) | DIP2B ATF1 | 32 |
14q22.2 | rs4444235 | 54410919 | C | T | 0.444 | 0.437 | 0.763 | 1.0 (0.8 to 1.3) | RPS3AP46 BMP4 | 12 |
15q13 | rs4779584 | 32994756 | T | C | 0.256 | 0.187 | 0.001 | 1.5 (1.2 to 1.9) |
SCG5 GREM1
FMN1 CRAC1 |
35 |
16q22.1 | rs9929218 | 68820946 | A | G | 0.280 | 0.278 | 0.921 | 1.0 (0.8 to 1.3) | CDH1 | 12 |
18q21.1 | rs4939827 | 46453463 | C | T | 0.486 | 0.491 | 0.864 | 1.0 (0.8 to 1.2) | SMAD7 | 14 |
19q13.1 | rs10411210 | 33532300 | T | C | 0.090 | 0.092 | 0.918 | 1.0 (0.7 to 1.4) | RHPN2 | 12 |
20p12.3 | rs961253 | 6404281 | A | C | 0.386 | 0.375 | 0.661 | 1.0 (0.9 to 1.3) | TARDBPL BMP2 | 12 |
20q13.33 | rs4925386 | 60921044 | T | C | 0.297 | 0.316 | 0.423 | 0.9 (0.7 to 1.1) | LAMA5 | 32 |
For SNP rs6983267, the minor allele originally reported (G) is the most frequent allele, both in our cases and controls.
The SNP positions are according to Human Build 36.3.
Chr, chromosome; MAF, minor allele frequency.