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. Author manuscript; available in PMC: 2014 Jan 13.
Published in final edited form as: Genes Chromosomes Cancer. 2012 Oct 29;52(3):225–236. doi: 10.1002/gcc.22022

Figure 5.

Figure 5

SULF2 enhances the efficacy of OKN-007 in growth inhibition of HCC xenografts. (A) OKN-007 represses tumor growth in mice bearing Huh7 xenografts (P = 0.0003). (B) In xenografts from Huh7 cells with suppressed expression of SULF2, there was no significant difference between tumor growth in the OKN-007 group versus the control group. (C) Knockdown of SULF2 blocked the growth inhibitory effect of OKN-007 in Huh7 xenografts. (D) Silencing SULF2 decreased the time to reach a tumor size of 2,000 mm3 (hazard ratio = 3.669; P = 0.0003), confirming that SULF2 is required for the antineoplastic function of OKN-007. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]