Table 4.

μCT analysis of distal femur trabecular bone volume and structural parameters in 3 months old wild-type (WT) and heterozygous (HT) mice of the indicated strains cross-bred with B6 ADO2 mice.

Mouse strains (generation)	μCT parameters	WT n=5-16	HT n=5-13	p-value
129 (N5)	BV/TV (%)	7.200±0.800	14.10±1.40	0.0002*
	Tb.N (1/mm)	2.317±0.180	4.009±0.244	<0.0001*
	Tb.Th (mm)	0.030±0.001	0.034±0.001	0.03*
	Tb.Sp (mm)	0.445±0.050	0.225±0.016	0.0005*
D2 (N5)	BV/TV (%)	6.100±0.600	8.800±0.700	0.008*
	Tb.N (1/mm)	1.172±0.154	2.584±0.194	0.002*
	Tb.Th (mm)	0.035±0.001	0.034±0.001	0.44
	Tb.Sp (mm)	0.626±0.070	0.381±0.034	0.007*
Balb/c (F1)	BV/TV (%)	13.600±1.900	16.400±2.000	0.03*
	Tb.N (1/mm)	3.168±0.345	4.263±0.449	0.06
	Tb.Th (mm)	0.041±0.002	0.038±0.001	0.26
	Tb.Sp (mm)	0.339±0.042	0.236±0.038	0.09
CD1 (F1)	BV/TV (%)	5.280±1.560	8.420±3.610	0.11
	Tb.N (1/mm)	1.180±0.290	2.210±0.980	0.12
	Tb.Th (mm)	0.045±0.002	0.038±0.002	0.05
	Tb.Sp (mm)	0.191±0.021	0.154±0.035	0.12

^*indicates statistically significant differences