Fig. 5.

HIV-hu-PBL LC-MS/MS metabolite analyses. FBMI was used in studies of HIV-1 infected human PBL reconstituted immune deficient mice. Metabolites were measured post mortem by LC-MS/MS in multiple subregions following ¹H MRS confirmation of Lac and NAA stability. Individual dissected regions did not demonstrate group differences results in (a) cortex or (b) hippocampus in mice reconstituted with human lymphocytes (open bars, n = 4) compared with HIV-1 infected hu-PBL mice (solid bars, n = 4). Error bars indicate standard error of the mean