Table I.

Aerosol Deposited (mean ± SD) in Nasal Cavities (Nasal), Upper Nasal Cavity and Maxillary Sinus (MS) Regions of Healthy Volunteers (In vivo) and in Two Nasal Cast Models: NC1 and NC2, Expressed as a Percentage of the Nebulizer Charge

	In vivo	NC1	NC2
Mesh nebulizer
Nasal	12.5 ± 2.7	10.8 ± 1.5*	7.2 ± 1.0**
Upper nasal cavity	1.6 ± 0.7	2.3 ± 0.2*	1.3 ± 0.3*
Maxillary sinuses	0.9 ± 0.5	0.9 ± 0.4*	0.7 ± 0.2*
Jet nebulizer
Nasal	3.7 ± 1.1	3.2 ± 0.3*	3.2 ± 0.4*
Upper nasal cavity	0.4 ± 0.4	0.5 ± 0.1*	0.3 ± 0.1*
Maxillary sinuses	0.2 ± 0.1	0.1 ± 0.1*	0.2 ± 0.1*

*: no significant difference between NC1 and In vivo or no significant difference between NC2 and In vivo (p > 0.1), ** significant differences between NC1 and In vivo or between NC2 and In vivo (p < 0.05)