Table 4.
Mean day (07:00–18:59) and night (19:00–06:59) micturition frequency at baseline and on day 1, day 8 and day 9 after administration of placebo or empagliflozin (25–100 mg doses)
| Empagliflozin dose | Number of patients | Baseline (pre-treatment) | Day 1 | Day 8 | Day 9 |
|---|---|---|---|---|---|
| Mean (SD) micturition day frequency | |||||
| Placebo | 12 | 4.8 (1.5) | 8.5 (2.4) | 8.1 (2.3) | 8.9 (2.8) |
| 2.5 mg qd | 9 | 3.9 (0.8) | 6.0 (1.2) | 6.6 (1.8) | 6.4 (1.9) |
| 10 mg qd | 9 | 3.8 (1.1) | 8.3 (1.7) | 6.8 (1.6) | 8.9 (1.7) |
| 25 mg qd | 9 | 4.4 (1.8) | 7.8 (2.6) | 7.0 (1.6) | 8.2 (2.0) |
| 100 mg qd | 9 | 4.1 (0.8) | 7.9 (2.4) | 6.9 (1.5) | 8.4 (2.5) |
| Mean (SD) micturition night frequency | |||||
| Placebo | 12 | 3.5 (1.8) | 4.2 (1.6) | 5 (1.3) | 3.8 (1.0) |
| 2.5 mg qd | 9 | 3.2 (0.5) | 3.7 (1.5) | 3.7 (1.2) | 3.4 (1.3) |
| 10 mg qd | 9 | 3.2 (0.7) | 3.8 (0.8) | 4.0 (1.7) | 3.7 (0.5) |
| 25 mg qd | 9 | 3.6 (2.0) | 4.3 (1.0) | 4.8 (1.6) | 4.1 (1.4) |
| 100 mg qd | 9 | 3.0 (0.9) | 3.6 (1.1) | 4.7 (1.5) | 3.7 (1.0) |
Data from the treated set (n = 48)
SD standard deviation